den Hoedt S, Dorst-Lagerwerf KY, de Vries HE, Rozemuller AJM, Scheltens P, Walter J, Sijbrands EJG, Martinez-Martinez P, Verhoeven AJM, Teunissen CE, Mulder MT. Sphingolipids in Cerebrospinal Fluid and Plasma Lipoproteins of APOE4 Homozygotes and Non-APOE4 Carriers with Mild Cognitive Impairment versus Subjective Cognitive Decline. J Alzheimers Dis Rep. 2023 May 3;7(1):339-354. doi: 10.3233/ADR220072. eCollection 2023.PMID: 37220621.
Marcuse F, Hoeijmakers JGJ, Hochstenbag M, Hamid MA, Keijzers M, Mané-Damas M, Martinez-Martinez P, Verschuuren J, Kuks J, Beekman R, van der Kooi AJ, van Doorn P, van Es M, Maessen JJG, De Baets MHV. Outcomes after robotic thymectomy in nonthymomatous versus thymomatous patients with acetylcholine-receptor-antibody-associated myasthenia gravis. Neuromuscul Disord. 2023 May;33(5):417-424. doi: 10.1016/j.nmd.2023.03.005. Epub 2023 Mar 16.PMID: 37037051.
van de Burgt N, van Doesum W, Grevink M, van Niele S, de Koning T, Leibold N, Martinez-Martinez P, van Amelsvoort T, Cath D. Psychiatric manifestations of inborn errors of metabolism: A systematic review. Neurosci Biobehav Rev. 2023 Jan;144:104970. doi: 10.1016/j.neubiorev.2022.104970. Epub 2022 Nov 25.PMID: 36436739 Review.
Fichtner ML, Hoehn KB, Ford EE, Mane-Damas M, Oh S, Waters P, Payne AS, Smith ML, Watson CT, Losen M, Martinez-Martinez P, Nowak RJ, Kleinstein SH, O'Connor KC. Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy. Acta Neuropathol Commun. 2022 Oct 28;10(1):154. doi: 10.1186/s40478-022-01454-0.PMID: 36307868.
Crivelli SM, Luo Q, Kruining DV, Giovagnoni C, Mané-Damas M, den Hoedt S, Berkes D, De Vries HE, Mulder MT, Walter J, Waelkens E, Derua R, Swinnen JV, Dehairs J, Wijnands EPM, Bieberich E, Losen M, Martinez-Martinez P. FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4. Biomed Pharmacother. 2022 Aug;152:113240. doi: 10.1016/j.biopha.2022.113240. Epub 2022 Jun 9.PMID: 35689862.
Mané-Damas M, Molenaar PC, Ulrichts P, Marcuse F, De Baets MH, Martinez-Martinez P, Losen M. Novel treatment strategies for acetylcholine receptor antibody-positive myasthenia gravis and related disorders. Autoimmun Rev. 2022 Jul;21(7):103104. doi: 10.1016/j.autrev.2022.103104. Epub 2022 Apr 19.PMID: 35452851 Review.
Tiquet M, La Rocca R, Kirnbauer S, Zoratto S, Van Kruining D, Quinton L, Eppe G, Martinez-Martinez P, Marchetti-Deschmann M, De Pauw E, Far J. FT-ICR Mass Spectrometry Imaging at Extreme Mass Resolving Power Using a Dynamically Harmonized ICR Cell with 1ω or 2ω Detection. Anal Chem. 2022 Jul 5;94(26):9316-9326. doi: 10.1021/acs.analchem.2c00754. Epub 2022 May 23.PMID: 35604839
Vinke AM, Zong S, Janssen JH, Correia-Hoffmann C, Mané-Damas M, Damoiseaux JGMC, de Vries JM, Pröpper D, Molenaar P, Losen M, Martinez Martinez P, Rouhl RPW. Autoimmune Encephalitis With mGluR1 Antibodies Presenting With Epilepsy, but Without Cerebellar Signs: A Case Report. Neurol Neuroimmunol Neuroinflamm. 2022 Apr 21;9(4):e1171. doi: 10.1212/NXI.0000000000001171. Print 2022 Jul.PMID: 35450924.
Crivelli SM, Giovagnoni C, Zhu Z, Tripathi P, Elsherbini A, Quadri Z, Pu J, Zhang L, Ferko B, Berkes D, Spassieva SD, Martinez-Martinez P, Bieberich E. Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles.
J Extracell Vesicles 2022 Jun;11(6):e12233. doi: 10.1002/jev2.12233.PMID: 35642450.
Koneczny I, Tzartos J, Mané-Damas M, Yilmaz V, Huijbers MG, Lazaridis K, Höftberger R, Tüzün E, Martinez-Martinez P, Tzartos S, Leypoldt F. IgG4
Autoantibodies in Organ-Specific Autoimmunopathies: Reviewing Class Switching, Antibody-Producing Cells, and Specific Immunotherapies.
Front Immunol. 2022, Mar 24;13:834342. doi: 10.3389/fimmu.2022.834342. eCollection 2022.PMID: 35401530 Review.
Mané-Damas M, Molenaar PC, Ulrichts P, Marcuse F, De Baets MH, Martinez-Martinez P, Losen M. Novel treatment strategies for acetylcholine receptor antibody-positive myasthenia gravis and related disorders. Autoimmun Rev. 2022, Apr 19:103104. doi: 10.1016/j.autrev.2022.103104. Online ahead of print.PMID: 35452851 Review.
Vinke AM, Zong S, Janssen JH, Correia-Hoffmann C, Mané-Damas M, Damoiseaux JGMC, de Vries JM, Pröpper D, Molenaar P, Losen M, Martinez Martinez P, Rouhl RPW. Autoimmune Encephalitis With mGluR1 Antibodies Presenting With Epilepsy, but Without Cerebellar Signs: A Case Report.
Neurol Neuroimmunol Neuroinflamm. 2022, Apr 21;9(4):e1171. doi: 10.1212/NXI.0000000000001171. Print 2022 Jul.PMID: 35450924.
Giovagnoni C, Ali M, Eijssen LMT, Maes R, Choe K, Mulder M, Kleinjans J, Del Sol A, Glaab E, Mastroeni D, Delvaux E, Coleman P, Losen M, Pishva E, Martinez-Martinez P, van den Hove DLA. Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach.
Neurobiol Aging. 2021, Jun;102:178-187. doi: 10.1016/j.neurobiolaging.2021.02.001. Epub 2021 Feb 7.PMID.
van de Burgt N, van Koningsbruggen S, Behrens L, Leibold N, Martinez-Martinez P, Mannens M, van Amelsvoort T. Screening for inborn errors of metabolism in psychotic patients using Next Generation Sequencing. J Psychiatr Res. 2021, Jun;138:125-129. doi: 10.1016/j.jpsychires.2021.03.060. Epub 2021 Apr 1.PMID: 33848968.
den Hoedt S, Crivelli SM, Leijten FPJ, Losen M, Stevens JAA, Mané-Damas M, de Vries HE, Walter J, Mirzaian M, Sijbrands EJG, Aerts JMFG, Verhoeven AJM, Martinez-Martinez P, Mulder MT. Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer's Disease and Control Mice.
Front Aging Neurosci. 2021, Oct 27;13:765252. doi: 10.3389/fnagi.2021.765252. eCollection 2021.PMID: 34776936.
Giovagnoni C, Crivelli SM, Losen M, Martinez-Martinez P. Immunofluorescence Labeling of Lipid-Binding Proteins CERTs to Monitor Lipid Raft Dynamics.
Methods Mol Biol. 2021;2187:327-335. doi: 10.1007/978-1-0716-0814-2_19.PMID: 32770516.
Hoffmann C, Zong S, Mané-Damas M, Stevens J, Malyavantham K, Küçükali Cİ, Tüzün E, De Hert M, van Beveren NJM, González-Vioque E, Arango C, Damoiseaux JGMC, Rutten BP, Molenaar PC, Losen M, Martinez-Martinez P. The search for an autoimmune origin of psychotic disorders: Prevalence of autoantibodies against hippocampus antigens, glutamic acid decarboxylase and nuclear antigens.
Schizophr Res. 2021, Feb;228:462-471. doi: 10.1016/j.schres.2020.12.038. Epub 2021 Feb 11.PMID: 33581586.
Crivelli SM, Luo Q, Stevens JAA, Giovagnoni C, van Kruining D, Bode G, den Hoedt S, Hobo B, Scheithauer AL, Walter J, Mulder MT, Exley C, Mold M, Mielke MM, De Vries HE, Wouters K, van den Hove DLA, Berkes D, Ledesma MD, Verhaagen J, Losen M, Bieberich E, Martinez-Martinez P. CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer's disease.
Alzheimers Res Ther. 2021, Feb 17;13(1):45. doi: 10.1186/s13195-021-00780-0.PMID: 33597019.
Crivelli SM, Giovagnoni C, Visseren L, Scheithauer AL, de Wit N, den Hoedt S, Losen M, Mulder MT, Walter J, de Vries HE, Bieberich E, and Martinez-Martinez P. Sphingolipids in Alzheimer's disease, how can we target them?
Adv Drug Deliv Rev 2020, Jan 3. pii: S0169-409X(20)30002-8. doi: 10.1016/j.addr.2019.12.003. [Epub ahead of print].
Martinez-Martinez P, and Titulaer MJ. Correspondence letter: Autoimmune psychosis.
Lancet Psychiatr 2020, 22 Jan.
van Kruining D, Luo Q, van Echten-Deckert G, Mielke MM, Bowman A, Ellis S, Oliveira TG, Martinez-Martinez P. Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods.
Adv Drug Deliv Rev. 2020;159:232-244. doi: 10.1016/j.addr.2020.04.009. Epub 2020 Apr 28.PMID: 32360155 Review.
Hoffmann C, Zong S, Mané-Damas M, Molenaar PC, Losen M, Titulaer MJ, Martinez-Martinez P; European Consortium of Autoimmune Mental Disorders. Absence of Autoantibodies Against Neuronal Surface Antigens in Sera of Patients With Psychotic Disorders. JAMA Psychiatry. 2020, Mar 1;77(3):322-325. doi: 10.1001/jamapsychiatry.2019.3679.PMID: 31746971.
Mané-Damas M, Vinke A, Hoffmann C, Zong S, Losen M, Molenaar PC, Damoiseaux J, Koudijs S, Rouhl RPW, Martinez-Martinez P. Unidentified Neuronal Surface IgG Autoantibodies in a Case of Hashimoto's Encephalopathy.
Front Immunol. 2020, Jul 7;11:1358. doi: 10.3389/fimmu.2020.01358. eCollection 2020.PMID: 32733453.
Crivelli SM, van Kruining D, Luo Q, Stevens JAA, Giovagnoni C, Paulus A, Bauwens M, Berkes D, de Vries HE, Mulder MT, Walter J, Waelkens E, Derua R, Swinnen JV, Dehairs J, Mottaghy FM, Losen M, Bieberich E, Martinez-Martinez P. Ceramide analog [18F]F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer's disease transgenic mice by functioning as a metabolic probe. Sci Rep. 2020, Nov 9;10(1):19354. doi: 10.1038/s41598-020-76335-4.PMID: 33168861, 22.
Zong S, Correia-Hoffmann C, Mané-Damas M, Kappelmann N, Molenaar PC, van Grootheest G, Penninx BWJH, Rouhl RPW, Losen M, Martinez-Martinez P. Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety. Transl Psychiatry 2020, Nov 23;10(1):404. doi: 10.1038/s41398-020-01083-y.PMID: 33230123.
Mané-Damas M, Hoffmann C, Zong S, Tan A, Molenaar PC, Losen M and Martinez-Martinez P. Autoimmunity in psychotic disorders. Where we stand, challenges and opportunities. Autoimmun Rev. 2019, 18:. Epub 2019 Jul 16. Review.
Takata K, Stathopoulos P, Cao M, Mané-Damas M, Fichtner ML, Benotti ES, Jacobson L, Waters P, Irani SR, Martinez-Martinez P, Beeson D, Losen M, Vincent A, Nowak RJ, and O'Connor KC. Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients.
JCI Insight 2019, 20;4(12). Jun 20..
Bogie J, Hoeks C, Schepers M, Tiane A, Cuypers A, Leijten F, Chintapakorn Y, Suttiyut T, Pornpakakul S, Struik D, Kerksiek A, Liu HB, Hellings N, Martinez-Martinez P, Jonker JW, Dewachter I, Sijbrands E, Walter J, Hendriks J, Groen A, Staels B, Lütjohann D, Vanmierlo T, and Mulder M. Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model. Sci Rep 2019, 9: 4908. doi: 10.1038/s41598-019-41399-4.
de Wit NM, den Hoedt S, Martinez-Martinez P, Rozemuller AJ, Mulder MT, and de Vries HE. Astrocytic ceramide as possible indicator of neuroinflammation. J Neuroinflammation 2019, 16:48. doi: 10.1186/s12974-019-1436-1.
Koneczny I, Rennspiess D, Marcuse F, Dankerlui N, Abdul Hamid M, Mané-Damas M, Maessen J, Van Schil P, Saxena A, Zisimopoulou P, Lazaridis K, Woodhall M, Karagiorgou K, Tzartos J, Tzartos S, De Baets MH, Molenaar PC, Marx A, Zur Hausen A, Losen M, and Martinez-Martinez P. Characterization of the thymus in Lrp4 myasthenia gravis: Four cases.
Autoimmun Rev 2019, 18:50-55.
Vinke AM, Schaper FLWVJ, Vlooswijk MCG, Nicolai J, Majoie MHJM, Martinez Martinez P, Hoffmann C, Damoiseaux JGMC, and Rouhl RPW. Anti-GAD antibodies in a cohort of neuropsychiatric patients.
Epilepsy Behav 2018, 82:25-28.
Hoffmann C, Stevens J, Zong S, van Kruining D, Saxena A, Küçükali Cİ, Tüzün E, Yalçınkaya N, De Hert M, González-Vioque E, Arango C, Lindstrom J, De Baets MH, Rutten BPF, van Os J, Molenaar P, Losen M, and Martinez-Martinez P. Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder.
PLoS One 222018, 6:13(12):e0208412.
Bode GH, Coué G, Freese C, Pickl KE, Sanchez-Purrà M, Albaiges B, Borrós S, van Winden EC, Tziveleka LA, Sideratou Z, Engbersen JFJ, Singh S, Albrecht K, Groll J, Möller M, Pötgens AJG, Schmitz C, Fröhlich E, Grandfils C, Sinner FM, Kirkpatrick CJ, Steinbusch HWM, Frank HG, Unger RE, and Martinez-Martinez P. An in vitro and in vivo study of peptide-functionalized nanoparticles for brain targeting: The importance of selective blood-brain barrier uptake. Nanomedicine 2017, 13:1289-1300.
de Wit NM, Snkhchyan H, den Hoedt S, Wattimena D, de Vos R, Mulder MT, Walter J, Martinez-Martinez P, Hoozemans JJ, Rozemuller AJ, and de Vries HE. Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.
J Alzheimers Dis 60:22917, 795-807.
den Hoedt S, Janssen CIF, Astarita G, Piomelli D, Leijten FPJ, Crivelli SM, Verhoeven AJM, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJG, Kiliaan AJ, and Mulder MT. Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels.
J Alzheimers Dis 2017, 60:769-781.
Losen M, Labrijn AF, van Kranen-Mastenbroek VH, Janmaat ML, Haanstra KG, Beurskens FJ, Vink T, Jonker M, 't Hart BA, Mané-Damas M, Molenaar PC, Martinez-Martinez P, van der Esch E, Schuurman J, de Baets MH, and Parren PWHI. Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys.
Sci Rep 2017, 7:992.
Zong S, Hoffmann C, Mané-Damas M, Molenaar P, Losen M, and Martinez-Martinez P. Neuronal Surface Autoantibodies in Neuropsychiatric Disorders: Are There Implications for Depression?
Front Immunol 2017, 8:752, Review.
Crivelli SM, Paulus A, Markus J, Bauwens M, Berkes D, De Vries HE, Mulder MT, Walter J, Mottaghy FM, Losen M, and Martinez-Martinez P. Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications.
J Alzheimers Dis 2017, 60:783-794.
Martinez Martinez P, and Mielke MM. Sphingolipids in Alzheimer's Disease and Related Disorders.
J Alzheimers Dis 2017, 60:753-756.
Scheiblich H, Schlütter A, Golenbock DT, Latz E, Martinez-Martinez P, and Heneka MT. Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
J Neurochem 2017, 143:534-550.
Saxena A, Stevens J, Cetin H, Koneczny I, Webster R, Lazaridis K, Tzartos S, Vrolix K, Nogales-Gadea G, Machiels B, Molenaar PC, Damoiseaux J, De Baets MH, Simon-Keller K, Marx A, Vincent A, Losen M and Martinez-Martinez P. Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient.
Sci Rep 2017,7:14426.
