Publications since 2005

P (1-68)

Koneczny I, Stevens JA, De Rosa A, Huda S, Huijbers MG, Saxena A, Maestri M, Lazaridis K, Zisimopoulou P, Tzartos S, et al.: IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients. J Autoimmun 2017, 77:104-115.

Stergiou C, Lazaridis K, Zouvelou V, Tzartos J, Mantegazza R, Antozzi C, Andreetta F, Evoli A, Deymeer F, Saruhan-Direskeneli G, et al.: Titin antibodies in "seronegative" myasthenia gravis--A new role for an old antigen.J Neuroimmunol 2016, 292:108-115.

Gomez AM, Stevens JA, Mane-Damas M, Molenaar P, Duimel H, Verheyen F, Cossins J, Beeson D, De Baets MH, Losen M, et al.: Silencing of Dok-7 in Adult Rat Muscle Increases Susceptibility to Passive Transfer Myasthenia Gravis.Am J Pathol 2016, 186:2559-2568.

den Hoedt S, Janssen CI, Astarita G, Piomelli D, Leijten FP, Crivelli SM, Verhoeven AJ, de Vries HE, Walter J, Martinez-Martinez P, et al.: Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels. J Alzheimers Dis 2016.

de Wit NM, Snkhchyan H, den Hoedt S, Wattimena D, de Vos R, Mulder MT, Walter J, Martinez-Martinez P, Hoozemans JJ, Rozemuller AJ, et al.: Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy. J Alzheimers Dis 2016.

Hoffmann C, Zong S, Mané-Damas M, Molenaar P, Losen M and Martinez-Martinez P. (2016) Autoantibodies in Neuropsychiatric Disorders. Antibodies.

De Vry J, Vanmierlo T, Martinez-Martinez P, Losen M, Temel Y, Boere J, Kenis G, Steckler T, Steinbusch HW, De Baets M, et al.: TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice.Behav Brain Res 2016, 296:15-25.

Bode GH, Coue G, Freese C, Pickl KE, Sanchez-Purra M, Albaiges B, Borros S, van Winden EC, Tziveleka LA, Sideratou Z, et al.: An in vitro and in vivo study of peptide-functionalized nanoparticles for brain targeting: The importance of selective blood-brain barrier uptake. Nanomedicine 2016, 13:1289-1300.

Tsonis AI, Zisimopoulou P, Lazaridis K, Tzartos J, Matsigkou E, Zouvelou V, Mantegazza R, Antozzi C, Andreetta F, Evoli A, et al.: MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study. J Neuroimmunol 2015, 284:10-17.

Nogales-Gadea G, Saxena A, Hoffmann C, Hounjet J, Coenen D, Molenaar P, Losen M, Martinez-Martinez P: Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells. J Vis Exp 2015:e52830.

Martinez-Martinez P, Molenaar PC, Losen M, Hoffmann C, Stevens J, de Witte LD, van Amelsvoort T, van Os J, Rutten BP: [Auto-immune disorders as a possible cause of neuropsychiatric syndromes].Tijdschr Psychiatr 2015, 57:183-191.

Losen M, Martinez-Martinez P, Molenaar PC, Lazaridis K, Tzartos S, Brenner T, Duan RS, Luo J, Lindstrom J, Kusner L: Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors--Recommendations for methods and experimental designs.Exp Neurol 2015, 270:18-28.

Logan CV, Cossins J, Rodriguez Cruz PM, Parry DA, Maxwell S, Martinez-Martinez P, Riepsaame J, Abdelhamed ZA, Lake AV, Moran M, et al.: Congenital Myasthenic Syndrome Type 19 Is Caused by Mutations in COL13A1, Encoding the Atypical Non-fibrillar Collagen Type XIII alpha1 Chain. Am J Hum Genet 2015, 97:878-885.

Kusner LL, Losen M, Vincent A, Lindstrom J, Tzartos S, Lazaridis K, Martinez-Martinez P: Guidelines for pre-clinical assessment of the acetylcholine receptor--specific passive transfer myasthenia gravis model-Recommendations for methods and experimental designs. Exp Neurol 2015, 270:3-10.

de Witte LD, Hoffmann C, van Mierlo HC, Titulaer MJ, Kahn RS, Martinez-Martinez P, European Consortium of Autoimmune Mental D: Absence of N-Methyl-D-Aspartate Receptor IgG Autoantibodies in Schizophrenia: The Importance of Cross-Validation Studies.JAMA Psychiatry 2015, 72:731-733.

de Witte L, Kromkamp M, Schoenmaker N, van Mierlo HC, Martinez-Martinez P, Palmen SJ, Sommer IE: [Auto-immune encephalitis in psychiatric practice].Tijdschr Psychiatr 2015, 57:446-451.

Bode GH, Pickl KE, Sanchez-Purra M, Albaiges B, Borros S, Potgens AJ, Schmitz C, Sinner FM, Losen M, Steinbusch HW, et al.: Detection of Peptide-based nanoparticles in blood plasma by ELISA.PLoS One 2015, 10:e0126136.

Zisimopoulou P, Evangelakou P, Tzartos J, Lazaridis K, Zouvelou V, Mantegazza R, Antozzi C, Andreetta F, Evoli A, Deymeer F, et al.: A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis.J Autoimmun 2014, 52:139-145.

Vrolix K, Fraussen J, Losen M, Stevens J, Lazaridis K, Molenaar PC, Somers V, Bracho MA, Le Panse R, Stinissen P, et al.: Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor. J Autoimmun 2014, 52:101-112.

Vlassaks E, Nikiforou M, Strackx E, Hutten M, Bekers O, Gazzolo D, Li Volti G, Martinez-Martinez P, Kramer BW, Gavilanes AW: Acute and chronic immunomodulatory changes in rat liver after fetal and perinatal asphyxia. J Dev Orig Health Dis 2014, 5:98-108.

Martinez-Martinez P, Molenaar PC, Losen M, de Baets MH: Glycine receptor antibodies in PERM: a new channelopathy. Brain 2014, 137:2115-2116.

Gomez AM, Willcox N, Vrolix K, Hummel J, Nogales-Gadea G, Saxena A, Duimel H, Verheyen F, Molenaar PC, Buurman WA, et al.: Proteasome inhibition with bortezomib depletes plasma cells and specific autoantibody production in primary thymic cell cultures from early-onset myasthenia gravis patients. J Immunol 2014, 193:1055-1063.

De Vry J, Vanmierlo T, Martinez-Martinez P, Losen M, Temel Y, Steinbusch H, De Baets M, Prickaerts J: Delivery of DNA into the central nervous system via electroporation.Methods Mol Biol 2014, 1121:157-163.

Bode GH, Losen M, Buurman WA, Veerhuis R, Molenaar PC, Steinbusch HW, De Baets MH, Daha MR, Martinez-Martinez P: Complement activation by ceramide transporter proteins.J Immunol 2014, 192:1154-1161.

Webster RG, Cossins J, Lashley D, Maxwell S, Liu WW, Wickens JR, Martinez-Martinez P, de Baets M, Beeson D: A mouse model of the slow channel myasthenic syndrome: Neuromuscular physiology and effects of ephedrine treatment. Exp Neurol 2013, 248:286-298.

Vlassaks E, Strackx E, Vles J, Nikiforou M, Martinez-Martinez P, Kramer BW, Gavilanes AW: Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats.J Neuroinflammation 2013, 10:14.

Vlassaks E, Mencarelli C, Nikiforou M, Strackx E, Ferraz MJ, Aerts JM, De Baets MH, Martinez-Martinez P, Gavilanes AW: Fetal asphyxia induces acute and persisting changes in the ceramide metabolism in rat brain. J Lipid Res 2013, 54:1825-1833.

Vlassaks E, Gavilanes AW, Vles JS, Deville S, Kramer BW, Strackx E, Martinez-Martinez P: The effects of fetal and perinatal asphyxia on neuronal cytokine levels and ceramide metabolism in adulthood.J Neuroimmunol 2013, 255:97-101.

Verschuuren JJ, Huijbers MG, Plomp JJ, Niks EH, Molenaar PC, Martinez-Martinez P, Gomez AM, De Baets MH, Losen M: Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4.Autoimmun Rev 2013, 12:918-923.

Mencarelli C, Martinez-Martinez P: Ceramide function in the brain: when a slight tilt is enough.Cell Mol Life Sci 2013, 70:181-203.

Martinez-Martinez P, Molenaar PC, Losen M, Stevens J, Baets MH, Szoke A, Honnorat J, Tamouza R, Leboyer M, Os JV, et al.: Autoantibodies to neurotransmitter receptors and ion channels: from neuromuscular to neuropsychiatric disorders. Front Genet 2013, 4:181.

Gomez AM, Vanheel A, Losen M, Molenaar PC, De Baets MH, Noben JP, Hellings N, Martinez-Martinez P: Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis.J Neuroimmunol 2013, 261:141-145

Fraussen J, Vrolix K, Claes N, Martinez-Martinez P, Losen M, Hupperts R, Van Wijmeersch B, Espino M, Villar LM, De Baets MH, et al.: Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients.J Neuroimmunol 2013, 261:98-107.

Cufi P, Dragin N, Weiss JM, Martinez-Martinez P, De Baets MH, Roussin R, Fadel E, Berrih-Aknin S, Le Panse R: Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis. Ann Neurol 2013, 73:281-293.

Mencarelli C, Bode GH, Vlamings R, Janssen ML, Losen M, De Baets MH, Steinbusch HW, Temel Y, Martinez-Martinez P: Unchanged expression of the ceramide transfer protein in the acute 6-OHDA neurodegenerative model.Neurosci Lett 2012, 506:39-43.

Mencarelli C, Bode GH, Losen M, Kulharia M, Molenaar PC, Veerhuis R, Steinbusch HW, De Baets MH, Nicolaes GA, Martinez-Martinez P: Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques.J Biol Chem 2012, 287:14897-14911.

Klooster R, Plomp JJ, Huijbers MG, Niks EH, Straasheijm KR, Detmers FJ, Hermans PW, Sleijpen K, Verrips A, Losen M, et al.: Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice. Brain 2012, 135:1081-1101.

Gomez AM, Willcox N, Molenaar PC, Buurman W, Martinez-Martinez P, De Baets MH, Losen M: Targeting plasma cells with proteasome inhibitors: possible roles in treating myasthenia gravis?Ann N Y Acad Sci 2012, 1274:48-59.

Basta I, Nikolic A, Losen M, Martinez-Martinez P, Stojanovic V, Lavrnic S, de Baets M, Lavrnic D: MuSK myasthenia gravis and Lambert-Eaton myasthenic syndrome in the same patient.Clin Neurol Neurosurg 2012, 114:795-797.

Vrolix K, Niks EH, Le Panse R, van Ostaijen-Ten Dam MM, Muris AH, Jol-van der Zijde CM, van Tol MJ, Losen M, Molenaar PC, van Zoelen EJ, et al.: Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis.J Neuroimmunol 2011, 232:158-165.

Timmers S, de Vogel-van den Bosch J, Hesselink MK, van Beurden D, Schaart G, Ferraz MJ, Losen M, Martinez-Martinez P, De Baets MH, Aerts JM, et al.: Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle.PLoS One 2011, 6:e14503.

Jaken RJ, van Gorp S, Joosten EA, Losen M, Martinez-Martinez P, De Baets M, Marcus MA, Deumens R: Neuropathy-induced spinal GAP-43 expression is not a main player in the onset of mechanical pain hypersensitivity. J Neurotrauma 2011, 28:2463-2473.

Gomez AM, Vrolix K, Martinez-Martinez P, Molenaar PC, Phernambucq M, van der Esch E, Duimel H, Verheyen F, Voll RE, Manz RA, et al.: Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis. J Immunol 2011, 186:2503-2513.

Chouliaras L, Sierksma AS, Kenis G, Prickaerts J, Lemmens MA, Brasnjevic I, van Donkelaar EL, Martinez-Martinez P, Losen M, De Baets MH, et al.: Erratum: gene-environment interaction research and transgenic mouse models of Alzheimer's disease. Int J Alzheimers Dis 2011, 2010:356862.

Vry J, Martinez-Martinez P, Losen M, Bode GH, Temel Y, Steckler T, Steinbusch HW, Baets M, Prickaerts J: Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain.Mol Ther 2010, 18:1183-1191.

Vrolix K, Fraussen J, Molenaar PC, Losen M, Somers V, Stinissen P, De Baets MH, Martinez-Martinez P: The auto-antigen repertoire in myasthenia gravis.Autoimmunity 2010, 43:380-400.

Mencarelli C, Losen M, Hammels C, De Vry J, Hesselink MK, Steinbusch HW, De Baets MH, Martinez-Martinez P: The ceramide transporter and the Goodpasture antigen binding protein: one protein--one function?J Neurochem 2010, 113:1369-1386.

Gomez AM, Van Den Broeck J, Vrolix K, Janssen SP, Lemmens MA, Van Der Esch E, Duimel H, Frederik P, Molenaar PC, Martinez-Martinez P, et al.: Antibody effector mechanisms in myasthenia gravis-pathogenesis at the neuromuscular junction. Autoimmunity 2010, 43:353-370.

Fraussen J, Vrolix K, Martinez-Martinez P, Losen M, Meulemans E, De Baets MH, Stinissen P, Somers V: A novel method for making human monoclonal antibodies. J Autoimmun 2010, 35:130-134.

De Vry J, Martinez-Martinez P, Losen M, Temel Y, Steckler T, Steinbusch HW, De Baets MH, Prickaerts J: In vivo electroporation of the central nervous system: a non-viral approach for targeted gene delivery.Prog Neurobiol 2010, 92:227-244.

De Vry J, Martinez-Martinez P, Losen M, Bode GH, Temel Y, Steckler T, Steinbusch HW, De Baets M, Prickaerts J: Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain.Mol Ther 2010, 18:1183-1191.

Chouliaras L, Sierksma AS, Kenis G, Prickaerts J, Lemmens MA, Brasnjevic I, van Donkelaar EL, Martinez-Martinez P, Losen M, De Baets MH, et al.: Gene-environment interaction research and transgenic mouse models of Alzheimer's disease. Int J Alzheimers Dis 2010, 2010.

ter Beek WP, Martinez-Martinez P, Losen M, de Baets MH, Wintzen AR, Verschuuren JJ, Niks EH, van Duinen SG, Vincent A, Molenaar PC: The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplates. Am J Pathol 2009, 175:1536-1544.

Mencarelli C, Hammels C, Van Den Broeck J, Losen M, Steinbusch H, Revert F, Saus J, Hopkins DA, De Baets MH, Steinbusch HW, et al.: The expression of the Goodpasture antigen-binding protein (ceramide transporter) in adult rat brain.J Chem Neuroanat 2009, 38:97-105.

Martinez-Martinez P, Phernambucq M, Steinbusch L, Schaeffer L, Berrih-Aknin S, Duimel H, Frederik P, Molenaar P, De Baets MH, Losen M: Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding.Neurobiol Dis 2009, 35:14-23.

Fraussen J, Vrolix K, Martinez-Martinez P, Losen M, De Baets MH, Stinissen P, Somers V: B cell characterization and reactivity analysis in multiple sclerosis.Autoimmun Rev 2009, 8:654-658.

Brasnjevic I, Steinbusch HW, Schmitz C, Martinez-Martinez P, European NanoBioPharmaceutics Research I: Delivery of peptide and protein drugs over the blood-brain barrier.Prog Neurobiol 2009, 87:212-251.

Revert F, Ventura I, Martinez-Martinez P, Granero-Molto F, Revert-Ros F, Macias J, Saus J: Goodpasture antigen-binding protein is a soluble exportable protein that interacts with type IV collagen. Identification of novel membrane-bound isoforms.J Biol Chem 2008, 283:30246-30255.

Molenaar PC: A relative weak leg muscle in the rolling Nagoya mouse as a model for Lambert-Eaton myasthenic syndrome. J Neuroimmunol 2008, 201-202:166-171.

Losen M, Martinez-Martinez P, Phernambucq M, Schuurman J, Parren PW, De Baets MH: Treatment of myasthenia gravis by preventing acetylcholine receptor modulation. Ann N Y Acad Sci 2008, 1132:174-179.

Kaptein SJ, Jungscheleger-Russell J, Martinez-Martinez P, Beisser PS, Lavreysen H, Vanheel A, De Baets MH, Bruggeman CA, Vink C, Losen M: Generation of polyclonal antibodies directed against G protein-coupled receptors using electroporation-aided DNA immunization. J Pharmacol Toxicol Methods 2008, 58:27-31.

Janssen SP, Phernambucq M, Martinez-Martinez P, De Baets MH, Losen M: Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil. J Neuroimmunol 2008, 201-202:111-120.

van der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martinez-Martinez P, Vermeulen E, den Bleker TH, Wiegman L, Vink T, Aarden LA, et al.: Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange.Science 2007, 317:1554-1557.

Martinez-Martinez P, Losen M, Duimel H, Frederik P, Spaans F, Molenaar P, Vincent A, De Baets MH: Overexpression of rapsyn in rat muscle increases acetylcholine receptor levels in chronic experimental autoimmune myasthenia gravis.Am J Pathol 2007, 170:644-657.

Roorda BD, Hesselink MK, Schaart G, Moonen-Kornips E, Martinez-Martinez P, Losen M, De Baets MH, Mensink RP, Schrauwen P: DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content. J Lipid Res 2005, 46:230-236.

Losen M, Stassen MH, Martinez-Martinez P, Machiels BM, Duimel H, Frederik P, Veldman H, Wokke JH, Spaans F, Vincent A, et al.: Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis. Brain 2005, 128:2327-2337.

Hoebeek FE, Stahl JS, van Alphen AM, Schonewille M, Luo C, Rutteman M, van den Maagdenberg AM, Molenaar PC, Goossens HH, Frens MA, et al.: Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control. Neuron 2005, 45:953-965.

Granero F, Revert F, Revert-Ros F, Lainez S, Martinez-Martinez P, Saus J: A human-specific TNF-responsive promoter for Goodpasture antigen-binding protein.FEBS J 2005, 272:5291-5305.

Bullens RW, Halstead SK, O'Hanlon GM, Veitch J, Molenaar PC, Willison HJ, Plomp JJ: Concanavalin A inhibits pathophysiological effects of anti-ganglioside GQ1b antibodies at the mouse neuromuscular synapse. Muscle Nerve 2005, 31:751-760.